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FS 725 Fermentation Microbiology 3. Prerequisite: BCH 451, MB 351.

Fermentation bioprocessing and characteristics, function and ecology of responsible microorganisms. Fermentative activities, growth responses and culture interactions related to metabolism, physiology and genetics of lactic acid bacteria and selected yeasts and molds. Current developments in starter culture technology and genetics; application to food and industrial fermentations.

FS 530 Post-Harvest Food Safety 3. Prerequisite: MB 351/352.

Background on the current issues and developments associated with post-harvest food safety, including biological, chemical, and physical food safety hazards. Additionally, regulations governing food safety and consumer perceptions.

FSA 530 Post-Harvest Food Safety 3. Prerequisite: MB 351/352.

Background on the current issues and developments associated with post-harvest food safety, including biological, chemical, and physical food safety hazards. Additionally, regulations governing food safety and consumer perceptions.

FSA 540 Food Safety and Public Health 3. Prerequisite: MB 351/352.

Issues and developments related to the relationship between food safety and public health, including emerging foodborne pathogens; virulence and pathogenicity; foodborne toxins; epidemiological techniques used in the investigation of foodborne disease; rapid detection methods; and quantitative microbial risk assessment in food safety.

FS 540 Food Safety and Public Health 3. Prerequisite: MB 351/352.

Issues and developments related to the relationship between food safety and public health, including emerging foodborne pathogens; virulence and pathogenicity; foodborne toxins; epidemiological techniques used in the investigation of foodborne disease; rapid detection methods; and quantitative microbial risk assessment in food safety.

IMM 751 Immunology 3. Prerequisite: BCH 451, GN 411, MB 351.

Introduction to mechanisms of immunity in man and animals. Emphasis on interactions between cells of the immune system in production of immune responses and the molecules in control of these interactions.

MB 751 Immunology 3. Prerequisite: BCH 451, GN 411, MB 351.

Introduction to mechanisms of immunity in man and animals. Emphasis on interactions between cells of the immune system in production of immune responses and the molecules in control of these interactions.

MB 714 Microbial Metabolic Regulation 3. Prerequisite: MB 351 and either BCH 351 or 451.

An integrative perspective on bacterial physiology and metabolism through analysis of metabolic regulatory functions.

MB 718 Introductory Virology 3. Prerequisite: BCH 451 or GN 411 or MB 351.

Introduction to principles of virology including: classification and nomenclature, epidemiology, structure, genome replication, gene expression strategies and cellular infection cycle. Major groups of viruses including those with DNA genomes and positive-sense or negative-sense RNA genomes.

MB 532 Soil Microbiology 4. Prerequisite: MB 351, CH 220.

Soil as a medium for microbial growth, the relation of microbes to important mineral transformations in soil, the importance of biological equilibrium and significance of soil microbes to environmental quality.

SSC 532 Soil Microbiology 4. Prerequisite: MB 351; CH 220.

Soil as a medium for microbial growth, the relation of microbes to important mineral transformations in soil, the importance of biological equilibrium and significance of soil microbes to environmental quality.

FS 521 Food Preservation 3. Corequisite: MB 351.

Food preservation methods. Emphasis on thermal, freezing, drying and fermentation processes and corresponding physical, chemical and organoleptic changes to products. Application of preservation schemes to the development of an overall processing operation.

PP 727 Ecology of Soil Ecosystems 3. Prerequisite: One course in: (SSC 332, SSC 511, SSC 521, or SSC 532), or ecology (BO 360 or CS 430), or microbiology (MB 351), or consent of instructor..

An interdisciplinary course primarily focusing on the interactions between soil organisms and their environment, and the ecological consequences of these diverse complex interactions. A broad range of topics, including soil biodiversity, plant-microbial interactions, trophic interactions, energy flow and nutrient cycling, and microbial controls over plant and ecosystem responses to natural and anthropogenic perturbation (e.g, tillage or global change components) are addressed.

MB 555 Microbial Biotechnology 3. Prerequisite: Undergraduate microbiology, genetics, and biochemistry course: MB351, BCH 351, and GN 311.

Overview of industrial microbiology focusing on current biotechnology methods (bacteria, yeast, fungi) employing rDNA, optimization of heterologous gene expression, microbial metabolic pathway engineering, metabolomics, protein engineering and recombinant antibodies. Genetic and pathway engineering strategies for developing new microbes to screen for new therapeutic compounds or overproduce: primary metabolites, antibiotics, biotherapeutic proteins, industrially useful enzymes, medical diagnostics, recombinant vaccines, biopolymers. Utilization of biofilms, methods to immobilize biocatalysts, and microbial kinetics are also covered. Field trip to local biotechnology company. Students cannot receive credit for both 455 and 555.

FS 405 Food Microbiology 3. Prerequisite: MB 351.

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/MB 405 and FS/MB 505.

MB 405 Food Microbiology 3. Prerequisite: MB 351.

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/MB 405 and FS/MB 505.

FS 505 Food Microbiology 3. Prerequisite: MB 351.

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/MB 405 and FS/MB 505.

MB 505 Food Microbiology 3. Prerequisite: MB 351.

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/MB 405 and FS/MB 505.

FS 406 Food Microbiology Lab 1. Prerequisite: MB 351 and Corequisite: FS 405 or FS 505.

Laboratory experience to complement FS/MB 405. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

MB 406 Food Microbiology Lab 1. Prerequisite: MB 351 and Corequisite: FS 405 or FS 505.

Laboratory experience to complement FS/MB 405. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

FS 506 Food Microbiology Lab 1. Prerequisite: MB 351 and Corequisite: FS 405 or FS 505.

Laboratory experience to complement FS/MB 405. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

MB 506 Food Microbiology Lab 1. Prerequisite: MB 351 and Corequisite: FS 405 or FS 505.

Laboratory experience to complement FS/MB 405. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

MB 352 General Microbiology Laboratory 1. Corequisite: MB 351.

Laboratory experience in general microbiology. Aseptic technique, isolation and identification of bacteria, staining and microscopy. Enumeration of bacteria and viruses. Students who have completed either MB (BEC) 320 or MB 354 may not take this course for credit.

MB 411 Medical Microbiology 3. Prerequisite: MB 351.

Comprehensive study of microbial pathogenesis and mammalian host resistance. Diagnosis, prevention, and therapy of common human diseases of microbial origin.

MB 414 Microbial Metabolic Regulation 3. Prerequisite: MB 351 and either BCH 351 or 451.

An integrative perspective on bacterial physiology and metabolism through an analysis of metabolic regulatory functions.

MB 451 Microbial Diversity 3. Prerequisite: MB 411 and (GN 311 or BCH 351 or BCH 451).

Molecular, biochemical, and evolutionary diversity of the microbial world, including Bacteria, Archaea, and Eukaryotes. Evolutionary perspective on microbial relationships, molecular methods of study and classical and modern biotechnological methods utilizing this genetic diversity to explore the microbial world and use the resulting insight to meet the needs of our own species.

MB 455 Microbial Biotechnology 3. Prerequisite: MB 351 and GN 311.

Introduction to industrial microbiology with focus on biotechnology including developments employing recombinant nucleic acid and monoclonal antibody techniques. Bioremediation, industrial enzymes, transgenic plants, biopesticides, medical diagnostics, recombinant vaccines production of important secondary metabolites, and other topics. Field trips to local biotechnology companies.

MB 461 Molecular Virology 3. Prerequisite: MB 351, MB 411.

Introduction to principles of molecular virology. Overview of classification and nomenclature, virus structure, interaction of viruses with cells, organisms (immunology, pathology), and populations (epidemiology). Detailed case studies from major groups of viruses; picornaviruses, togaviruses, orthomyxoviruses, retroviruses, polyomaviruses, and herpesviruses.

MB 480 Current Issues in Microbiology 1. Prerequisite: SMB majors or minors, Senior standing, and MB 351.

Library research on current topics in all areas of microbiology. Presentation of research results orally and in the form of a major term paper.

MB 354 Inquiry-Guided Microbiology Lab 1. Corequisite: MB 351.

Inquiry-guided laboratory experience in general microbiology, for microbiology majors and honors students, and those desiring a more rigorous exposure to this topic. Aseptic technique, isolation and identification of bacteria, staining and microscopy, and Koch's postulates. Restricted to microbiology majors and honor's students. Others require departmental permission. Credit is not allowed for both MB 354 and either Mb 320 or MB 352.

BIO 484 Capstone Course in Human Biology 3. Prerequisite: C- or better in BIO 421, MB 351 and one of the following: BCH 351 or BCH 451 or GN 311 or ST 311..

Topical problems in human biology. BIO 484 provides a challenging opportunity for students to integrate and apply knowledge and skills gained from their major studies. Emphasis will be placed on collaborative learning and on effective, professional communication. Topics and instructors will vary from semester to semester. Priority will initially be given to seniors in the HB curriculum; other students with the necessary prerequisites will be admitted on a space available basis.

MB 351 General Microbiology 3. Prerequisite: One Biology course (BIO 181, BIO 183, ZO 150 or ZO 160) and one Organic Chemistry course (CH 221 or CH 220).

Rigorous introduction to basic principles of microbiology for students in biological and agricultural sciences and for all students planning to take further courses in microbiology.

BAE 474 Principles and Applications of Ecological Engineering 3. Prerequisites: (MB 351 or PB 321 or PB 360 or SSC 332) and BAE 371.

Governing principles of ecological engineering and the advanced biological, chemical, and physical conditions that determine the design of biological systems. Emphasis on 1) stream and wetland ecosystem restoration and 2) natural treatment systems for groundwater, stormwater, and wastewater such as riparian buffers, bioretention cells, and stormwater wetlands. A class field trip is required during non-scheduled time.

BEC 440 Expression Systems in Biomanufacturing 1 3. Prerequisite: BEC 363 or (MB 351 and MB 352).

Introduction to bacterial and yeast expression systems, their advantages and disadvantages. Basic techniques in molecular biology, cell transformation and optimization of protein expression. Selection, archiving and characterization of production line. Study of parameters affecting expression and yield. The lab portion of the course provides students with practical experience in DNA and protein expression techniques in bacterial and yeast expression systems.Credit not given for both.

BEC 540 Expression Systems in Biomanufacturing 1 3. Prerequisite:MB 351/352.

Introduction to bacterial and yeast expression systems, their advantages and disadvantages. Basic techniques in molecular biology, cell transformation and optimization of protein expression. Selection, archiving and characterization of production line. Study of parameters affecting expression and yield. The lab portion of the course provides students with practical experience in DNA and protein expression techniques in bacterial and yeast expression systems.Credit not given for both.

MB 470 Emerging and Re-emerging Infectious Diseases 3. Prerequisite: MB 351.

Human behavior plays a big part in the emergence and reemergence of infectious diseases. Humanity encroaches consistently into previously uninhabited parts of the planet increasing the risk of exposure to novel pathogens that have the potential to jump into the human host or livestock. In addition to exposure to new diseases the complexities of politics and global relations often create opportunities for the re-emergence of infections that were once thought to be under control. This course aims to provide students interested in the health sciences with a foundation to understand the principles governing emergence of diseases.

MB 441 Immunology 3. P: C- or better in (MB 351 or BCH 351 or BCH 451 or BIO 414 or PB 414 or BIO 421).

Introduction to principles of molecular immunology. Overview of immune system development and function, and discussions of ongoing scientific research regarding immune regulation.

BAE 425 Industrial Microbiology and Bioprocessing 3. Prerequisite: Junior or higher standing in CALS or COE; MB 351.

Introduction to the structure and functions of microbial cells and their cultivation and utilization in bioprocess engineering. Fermentation systems and downstream processing methods. Enzyme kinetics, production and application. Biomanufacturing of fuels, industrial chemicals, pharmaceuticals, food additives and food products such as beer, wine, cheese and yogurt Microbial biomass production. Introduction to environmental biotechnology including waste water treatment, bioremediation and biomining. Biodeterioration and its control. Product development, regulations and safety. Field trip(s) are an essential educational component of the course and are required. Credit will not be given for both BAE(BBS) 425 and BAE 525.

BAE 525 Industrial Microbiology and Bioprocessing 3. Prerequisite: MB 351.

Introduction to the structure and functions of microbial cells and their cultivation and utilization in bioprocess engineering. Fermentation systems and downstream processing methods. Enzyme kinetics, production and application. Biomanufacturing of fuels, industrial chemicals, pharmaceuticals, food additives and food products such as beer, wine, cheese and yogurt Microbial biomass production. Introduction to environmental biotechnology including waste water treatment, bioremediation and biomining. Biodeterioration and its control. Product development, regulations and safety. Field trip(s) are an essential educational component of the course and are required. Credit will not be given for both BAE(BBS) 425 and BAE 525.

BIT 510 Core Technologies in Molecular and Cellular Biology 4. Prerequisite: Equivalent of CH 223 and (MB 351 or GN 311).

Basic technologies of recombinant DNA procedures, gene expression, isolation and identification of nucleic acids and proteins.

BCH 453 Biochemistry of Gene Expression 3. Prerequisite: BCH 451, Corequisite: GN 311, MB 351.

Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit is not allowed for both BCH 453 and BCH 553.

BCH 553 Biochemistry of Gene Expression 3. Prerequisite: BCH 451, Corequisite: GN 311, MB 351.

Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit is not allowed for both BCH 453 and BCH 553.

BBS 426 Upstream Biomanufacturing Laboratory 2. Prerequisite: (MB 351 and FS 231) CHE/BEC 463.

This course is an introduction to current food manufacturing practice (CGMP) as applied to the growth of microbial cells in bioreactors. Hands-on experience is obtained in the operation and control of 30 liter bioreactors to study agitation, oxygen transfer, cleaning, sterilization, media preparation and the growth of recombinant E. coli for protein production. Credit will not be awarded in both BBS 426 and BBS/FS 526. This is an eight week course.

FS 426 Upstream Biomanufacturing Laboratory 2. Prerequisite: (MB 351 and FS 231) CHE/BEC 463.

This course is an introduction to current food manufacturing practice (CGMP) as applied to the growth of microbial cells in bioreactors. Hands-on experience is obtained in the operation and control of 30 liter bioreactors to study agitation, oxygen transfer, cleaning, sterilization, media preparation and the growth of recombinant E. coli for protein production. Credit will not be awarded in both BBS 426 and BBS/FS 526. This is an eight week course.

BEC 426 Upstream Biomanufacturing Laboratory 2. Prerequisite: (MB 351 and FS 231) CHE/BEC 463.

This course is an introduction to current food manufacturing practice (CGMP) as applied to the growth of microbial cells in bioreactors. Hands-on experience is obtained in the operation and control of 30 liter bioreactors to study agitation, oxygen transfer, cleaning, sterilization, media preparation and the growth of recombinant E. coli for protein production. Credit will not be awarded in both BBS 426 and BBS/FS 526. This is an eight week course.

BBS 526 Upstream Biomanufacturing Laboratory 2. Prerequisite: (MB 351 and FS 231) CHE/BEC 463.

This course is an introduction to current food manufacturing practice (CGMP) as applied to the growth of microbial cells in bioreactors. Hands-on experience is obtained in the operation and control of 30 liter bioreactors to study agitation, oxygen transfer, cleaning, sterilization, media preparation and the growth of recombinant E. coli for protein production. Credit will not be awarded in both BBS 426 and BBS/FS 526. This is an eight week course.

FS 526 Upstream Biomanufacturing Laboratory 2. Prerequisite: (MB 351 and FS 231) CHE/BEC 463.

This course is an introduction to current food manufacturing practice (CGMP) as applied to the growth of microbial cells in bioreactors. Hands-on experience is obtained in the operation and control of 30 liter bioreactors to study agitation, oxygen transfer, cleaning, sterilization, media preparation and the growth of recombinant E. coli for protein production. Credit will not be awarded in both BBS 426 and BBS/FS 526. This is an eight week course.