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Biochemistry (BCH)

BCH - Biochemistry Courses

BCH 101 Introduction to Microbiology and Biochemistry Laboratory Practices 3.

Curricular bridge between high school and college for high school and transitional students. A "hands on" introduction to fundamentals in Microbiology and Biochemistry. Bacterial isolation, identification and growth using aseptic technique, microscopy, and metabolic analysis. Experiments with DNA isolation and analysis, protein isolation, and purification, and enzyme kinetics. Lectures and readings on background, theory and applications of these techniques. Field trips to university and industry research laboratories. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS) as well as other pre-college, transitional and early-college programs and is offered as 4 week intensive course. Applicants should have completed high school courses in biology and chemistry. Students must have completed no more than 30 credit hours. Departmental approval is required for current NCSU students.

BCH 103 Introduction to Biochemistry 1.

Introduction to curriculum and career requirements for biochemistry and being a successful student at NCSU. Emphasis is placed on curricular requirements, interactions with faculty and students in the Department of Molecular and Structural Biochemistry, introduction to key resource programs on campus, exposure to research opportunities and ongoing career planning. Enrollment is limited to new or transfer Biochemistry majors with less than 45 hours.

BCH 220 Role of Biotechnology in Society 3.
Prerequisite: BIO 181, CH 101.

Biotechnology and Societing is an introductory science course that takes a semi-technical look at the emerging role of biotechnology in human society. Expectations are that students will gain an appreciation for biotechnology, the ability to understand how biotechnology works. Offered only in Poland through Study Abroad (4-week course). Departmental approval required.

BCH 330 Physical Biochemistry 3.
P: (CH 201 or CH 203) and (BCH 351 or BCH 451) and (MA 231 or MA 242) and (PY 208 or PY 212).

This course provides a descriptive survey of the concepts of physical chemistry with emphasis on their use in applications designed to characterize and manipulate biological molecules and systems. Topics are drawn from thermodynamics (bonding, protein folding energies, linkage, specostropic and differential scanning calorimetric binding measurements), kinetics (enzymatic catalysis, perturbation techniques), statistical mechanics (distributions, ensembles, molecular mechanical & dynamics calculations), electrochemistry, hydrodynamics (diffusion, friction, electrophoresis, viscosity, sedimentation, organism size and shape), quantum mechanics (wave functions operators, uncertainty principle, dipoles, orbitals and resonance energy coupling), and spectroscopy (absorbance and light scattering, fluorescence, nuclear and electronic paramagnetic resonance, MR imaging and x-ray diffraction).

BCH 351 General Biochemistry 4.
Prerequisite: (CH 223 or CH 227) and BIO 183.

This course is an introduction to the basic principles of biochemistry. It emphasizes biochemical structures, properties, and functions, including enzyme kinetics and major metabolic processes. It discusses amino acids and proteins, carbohydrates, lipids, and nucleic acids. The pathways discussed will include glycolysis, gluconeogenesis, and the Krebs cycle. It can serve as a prerequisite for BCH 452 with permission of the department. This course is designed for those students who are not majoring in Biochemistry and do not require a more comprehensive introduction to biochemistry. It is not intended for graduate students. Credit is not allowed for both BCH 351 and BCH 451.

BCH 451 Principles of Biochemistry 4.
Prerequisite: CH 223 or CH 227.

Introduction to the fundamental principles of biochemistry. Emphasis on biochemical structures, properties, functions and interactions, including enzyme kinetics and central pathways of metabolism.

BCH 452 Introductory Biochemistry Laboratory 2.
Corequisite: BCH 451.

Laboratory experience to complement BCH 451. Basic skills in the use of volumetric equipment, spectrophotometers, chromatography, and electrophoresis. Manipulation and assay of small quantities of biological materials, and analysis of laboratory data.

BCH 453 Biochemistry of Gene Expression 3.
Prerequisite: BCH 451, Corequisite: GN 311, MB 351.

Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit is not allowed for both BCH 453 and BCH 553.

BCH 454 Advanced Biochemistry Laboratory 4.
Prerequisite: BCH 452, Corequisite: BCH 453.

Techniques in molecular biology and protein purification. Cloning and expression of a eukaryotic gene in bacteria followed by purification of the eukaryotic gene product. Microanalysis of DNA, RNA and protein.

BCH 455 Proteins and Molecular Mechanisms 3.
Prerequisite: BCH 451, BCH 453/553.

Principles of protein structure and function, protein folding, enzymology, ligand binding, protein transport, and metabolic pathways.

BCH 492 External Learning Experience 1-6.
Prerequisite: Sophomore standing.

A learning experience in agriculture and life sciences within an academic framework that utilizes facilities and resources which are external to the campus. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and academic dean prior to the experience.

BCH 493 Special Problems in Biochemistry 1-6.
Prerequisite: Sophomore standing.

A learning experience in agriculture and life sciences within an academic framework that utilizes campus facilities and resources. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and the academic dean prior to the experience.

BCH 495 Special Topics in Biochemistry 1-5.
Prerequisite: Junior standing..

Offered as needed to present materials not normally available in regular BCH departmental courses or for new BCH courses on a trial basis.

BCH 552 Experimental Biochemistry 3.
Prerequisite: BCH 452;BCH 453.

An advanced laboratory to give students practical experiences in purification and quantitative characterization of enzymes and nucleic acids. Studies with carbohydrates and membrane lipids. Credit may be applied toward biotechnology minor.

BCH 553 Biochemistry of Gene Expression 3.
Prerequisite: BCH 451, Corequisite: GN 311, MB 351.

Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit is not allowed for both BCH 453 and BCH 553.

BCH 555 Proteins and Molecular Mechanisms 3.
Prerequisite: BCH 451, BCH 453/553.

Principles of protein structure and function, protein folding, enzymology, ligand binding, protein transport, and metabolic pathways.

BCH 560 Molecular Biology for Teachers 3.

Introduction to molecular biology for teachers. Emphasis will be on developing basic laboratory skills applicable to middle or high school biology classes. Teachers will develop their own labs during the last week of class. This is an intensive three-week class, five hours per day. Students should have at least one biotechnology course before enrolling in this course. Prior secondary school teaching experience preferred.

BCH 571 Regulation of Metabolism 3.
Prerequisite: BCH 451, GN 411, a course in physiology, cell biology.

Study of hormonal, enzymatic and molecular-genetic regulation of carbohydrate and lipid metabolism; emphasis on mammalian species.

BCH 590 Special Topics in Biochemistry 1-6.
Prerequisite: BCH 451.

The study of topics of special interest by small groups of students instructed by members of the faculty.

BCH 610 Special Topics 1-6.
Prerequisite: BCH 451.

The study of topics of special interest by small groups of students instructed by members of the faculty.

BCH 615 Special Topics In Biochemistry 1-6.
Prerequisite: Graduate standing in BCH.

Critical study of special problems and selected topics of current interest in biochemistry and related fields.

BCH 670 Laboratory Rotations 1.
Prerequisite: BCH 451.

Performance of highly directed research by biochemistry students in one or more laboratories of student's choice prior to beginning thesis research. Each laboratory experience lasts 5 weeks and given 1 hr. of credit. No more than 4 credits earned inBCH 692.

BCH 685 Master's Supervised Teaching 1-3.
Prerequisite: Master's student.

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

BCH 690 Master's Examination 1-9.
Prerequisite: Master's student.

For students in non-thesis master's programs who have completed all other requirement of the degree except preparing for and taking the final master's exam.

BCH 693 Master's Supervised Research 1-9.
Prerequisite: Master's student.

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

BCH 695 Master's Thesis Research 1-9.
Prerequisite: Master's student.

Thesis research.

BCH 696 Summer Thesis Research 1.
Prerequisite: Master's student.

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

BCH 699 Master's Thesis Preparation 1-9.
Prerequisite: Master's student.

For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their thesis.

BCH 701 Macromolecular Structure 3.
Prerequisite: BCH 453 or BCH 553; a course in physical chemistry highly recommended.

Introduction to the current understanding and methods used for the study of structures, thermodynamics and conformational dynamics of proteins, nucleic acids and membranes.

BCH 703 Macromolecular Synthesis and Regulation 3.
Prerequisite: BCH 453 or BCH 553.

Biochemistry of DNA replication, transcription, RNA processing and translation. Development of key concepts, techniques and applications relating to mechanisms and regulation of these processes by analysis of primary literature.

BCH 705 Molecular Biology Of the Cell 3.
Prerequisite: BCH 701 or BCH 703.

Regulation of cellular processes, membrane structure and function, signal transduction, protein trafficking/sorting, secretion, photosynthesis and nitrogen fixation.

BCH 710 Biological Scanning Electron Microscopy 2.
Prerequisite: Graduate standing with some biological background.

On demand. Theory and application of scanning electron microscopy, including specimen preparation, microscope alignment and operation, performance evaluation, interpretation of problems and darkroom technique. (Limited to 8 students with prior approval of instructor.).

BCH 751 Biophysical Chemistry 3.
Prerequisite: BCH 451; one sem. of physical chemistry.

Fundamental and practical aspects of biological macromolecular structure, thermodynamics, hydrodynamics, kinetics and spectroscopy with emphasis on mechanisms in functionally important structural transformations.

BCH 760 Protein Crystallography and Macromolecular Modeling 3.
Prerequisite: BCH 455 or BCH 555 or equivalent.

Basic principles and practice of protein crystallography and the application of molecular dynamics to evaluate structural models. The computer lab provides hands-on experience in structure determination, refinement, model building, and molecular dynamics using CHARMM.

BCH 761 Advanced Molecular Biology Of the Cell 3.
Prerequisite: BCH 553 or BCH 703 or GN 701.

An advanced graduate class involving integrated approaches to complex biological questions at the molecular level, encompassing biochemistry, cell biology and molecular genetics. The course will focus on an important, current area of research in eukaryotic biology using the primary scientific literature, and will involve class discussions, oral presentations, and a written research proposal.

BCH 763 Biochemistry Of Hormone Action 3.
Prerequisite: BCH 705 or GN 757.

Study of well-defined models of steroid and protein hormone action via lectures, assigned readings and discussions. Students add breadth to the course and depth to their own understanding by searching the literature and writing or lecturing about a particular hormone of their own choosing.

BCH 768 Nucleic Acids: Structure and Function 3.
Prerequisite: BCH 701 and 703.

An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions.

BCH 770 Enzyme Kinetics and Mechanisms 3.
Prerequisite: BCH 451 and BCH 455/555 or equivalent..

An advanced course in enzyme kinetics and mechanisms with particular emphasis on experimental design and interpretation. The first half of the course covers the derivation and application of single and multisubstrate kinetic equations, inhibition and pre-steady state kinetics. The second half of the course covers fundamental chemical and physical principles of enzyme catalysis and specificity.

BCH 801 Seminar In Biochemistry 1.

BCH 810 Special Topics 1-6.
Prerequisite: BCH 451.

The study of topics of special interest by small groups of students instructed by members of the faculty.

BCH 815 Advanced Special Topics 1-6.
Prerequisite: Graduate standing in BCH.

Critical study of special problems and selected topics of current interest in biochemistry and related fields.

BCH 870 Laboratory Rotations 1.
Prerequisite: BCH 451.

Performance of highly directed research by biochemistry students in one or more laboratories of student's choice prior to beginning thesis research. Each laboratory experience lasts 5 weeks and given 1 hr. of credit. No more than 4 credits earned inBCH 692.

BCH 885 Doctoral Supervised Teaching 1-3.
Prerequisite: Doctoral student.

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

BCH 890 Doctoral Preliminary Examination 1-9.
Prerequisite: Doctoral student.

For students who are preparing for and taking written and/or oral preliminary exams.

BCH 893 Doctoral Supervised Research 1-9.
Prerequisite: Doctoral student.

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

BCH 895 Doctoral Dissertation Research 1-9.
Prerequisite: Doctoral student.

Dissertation research.

BCH 896 Summer Dissertation Research 1.
Prerequisite: Doctoral student.

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

BCH 899 Doctoral Dissertation Preparation 1-9.
Prerequisite: Doctoral student.

For students who have completed all credit hours, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.